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Computation Toxicology and New Approach Methodologies

Department of Health and Human Services
Agency for Toxic Substances and Disease Registry

Summary

This position is located in the Agency for Toxic Substances and Disease Registry, headquartered in Atlanta, Georgia.

Overview

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Accepting applications
Location
1 vacancy in the following location:
Work site options
Telework eligible
No
Remote job
No
Relocation expenses reimbursed
No
Salary
$0 - $0 without compensation
Pay scale & grade
GS 00
Promotion potential
None
Pay scale and grade determines the salary of the job.
Work schedule
Part-time
Travel Required
Not required
Appointment type
Internships
Occupations and job series
Supervisory status
No
Federal service type
This job is in the Competitive Service
Represented by a union
No
Drug test
No
Security clearance
Not Required
Position sensitivity and risk
Non-sensitive (NS)/Low Risk
Jobs require a background check and some require a security clearance. The type depends on the job.
Background check type
Financial disclosure required
No
Some jobs require financial disclosure to identify conflicts of interests.
Announcement number
HHS-ATSDR-SWEP-26-13044876
Control number
883780100

Duties

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WHAT YOU'LL BE DOING DAY TO DAY

As a Student Volunteer you will use your knowledge of and experience with Computational Toxicology and New Approach Methodologies (NAM) to optimize business results and customer experience by:

  • Conduct comprehensive literature searches on Computational Toxicology and NAMs related to the health effects of microplastics and Nano plastics.
  • Perform systematic or scoping literature reviews using established review methodologies.
  • Critically evaluate and synthesize scientific evidence on computational toxicology approaches, including quantitative structure-activity relationship (QSAR) models, physiologically based pharmacokinetic (PBPK) modeling, machine learning, and in silico exposure assessment methods.
  • Review and summarize the application of NAMs, including in vitro methods, high-throughput screening, organ-on-a-chip technologies, omics approaches, and adverse outcome pathway (AOP) frameworks.
  • Analyze scientific literature to identify strengths, limitations, research gaps, and opportunities for integrating computational and experimental methods for risk assessment.
  • Organize, manage, and document scientific references using reference management software.
  • Prepare clear, concise written summaries, evidence tables, and technical reports to communicate findings.
  • Identify reproducible workflows, open-source tools, and publicly available data resources that support transparent and reproducible environmental health research.
  • Collaborate with CDC scientists and multidisciplinary teams to support evidence synthesis and inform environmental and public health research priorities.
  • Characterizing the current state of knowledge on the physicochemical properties of microplastics and nanoplastics that influence toxicity.
  • Identifying how computational and alternative methods are being applied to model their behavior, fate, and biological interactions.
  • Evaluating the strengths, limitations, and data gaps associated with these approaches.
  • Highlighting opportunities for integrating computational models with experimental NAM data to improve risk assessment.

Requirements

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Conditions of employment

  • U.S. Citizenship required
  • Registered or exempt from Selective Service (www.sss.gov)
  • Suitable for federal employment
  • Proof of student status must be submitted with the application
  • All applicants must be in good academic standing
  • Students must provide official transcripts, if selected
  • Appointment will be subject to the applicant's successful completion of a background security investigation and favorable adjudication. All information concerning qualifications is subject to investigation.
  • Documentation that you present for purposes of completing the Department of Homeland Security (DHS) Form I-9 will be verified through the DHS "E-Verify" System.
  • Volunteers must meet the federal minimum working age (5 CFR §308.102(a)).

Qualifications

Applicants must have:

  • A background in environmental health, toxicology, public health, environmental science, or a related scientific field.
  • Experience conducting scientific literature searches and critically evaluating published research.
  • Familiarity with computational toxicology concepts, including QSAR, PBPK modeling, machine learning, and other computational approaches used to interpret toxicological data.
  • Experience conducting systematic reviews, scoping reviews, or other structured evidence synthesis methods.
  • Proficiency using reference management software (e.g., EndNote, Zotero, Mendeley, or similar).
  • Strong scientific writing, technical communication, and analytical skills.
  • Experience organizing, synthesizing, and summarizing complex scientific information from multiple sources.
Preference may be given to applicants with:
  • Knowledge of New Approach Methodologies (NAMs), including in vitro testing, omics technologies, organ-on-a-chip systems, and adverse outcome pathway (AOP) frameworks.
  • Familiarity with environmental exposure assessment and risk assessment principles.
  • Knowledge of regulatory frameworks related to chemical safety, environmental health, or toxicology.
  • Experience identifying and evaluating open-source scientific tools, databases, and reproducible research workflows.
  • Ability to work independently while collaborating effectively in a multidisciplinary scientific environment.
Volunteers must meet the definition of a student defined as "an individual enrolled not less than half-time in a high school, trade school, technical or vocational institute, junior college, college, university, or other accredited educational institution (5 U.S.C. §3111(a) and 5 CFR §308.101)" throughout the duration of their volunteer service, except during acceptable breaks in education as described in 5 CFR §308.101.

Additional information

THINGS YOU NEED TO KNOW

Candidates should be committed to improving the efficiency of the Federal government, passionate about the ideals of our American republic, and committed to upholding the rule of law and the United States Constitution.

Candidates should be committed to improving the efficiency of the Federal government, passionate about the ideals of our American republic, and committed to upholding the rule of law and the United States Constitution.

How you will be evaluated

You will be evaluated for this job based on how well you meet the qualifications above.

Qualification determinations will be made based solely on the information submitted in the application package. Selection for this unpaid volunteer internship does not constitute employment with the Department of Health and Human Services and confers no entitlement to compensation, future employment, or non-competitive conversions.

Agency for Toxic Substances and Disease Registry

Become a part of the Department that touches the lives of every American! At the Department of Health and Human Services (HHS) you can give back to your community, state, and country by making a difference in the lives of Americans everywhere. It is the principal agency for protecting the health of citizens. Join HHS and help to make our world healthier, safer, and better for all Americans.

Agency contact information

HHS HELPDESK
Email
ASKOHR@hhs.gov
Address
Agency for Toxic Substances and Disease Registry
200 Independence Avenue, S.W.
Washington, DC 20201
US

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