NIST is seeking a RNA Therapeutic Analyst to develop and implement novel analytical methods for RNA-based therapeutics. The position supports NIST's biomanufacturing program and primarily involves the use of chromatographic and mass spectrometric methods.
This notice is issued under direct-hire authority to recruit new talent to occupations for which NIST has a severe shortage of candidates.
Summary
NIST is seeking a RNA Therapeutic Analyst to develop and implement novel analytical methods for RNA-based therapeutics. The position supports NIST's biomanufacturing program and primarily involves the use of chromatographic and mass spectrometric methods.
This notice is issued under direct-hire authority to recruit new talent to occupations for which NIST has a severe shortage of candidates.
Research and develop novel analytical methods for the assessment of critical quality attributes (CQAs) of RNA-based biotherapeutics
Design and implement cutting-edge chromatographic and mass spectrometric methods for the detection and characterization of impurities in RNA biotherapeutics
Apply specialized experience in RNA-based therapeutics to design and characterize reference materials to meet stakeholder needs
Analyze and interpret research data and disseminate results through publications and presentations
Males born after 12-31-59 must be registered for Selective Service
Suitable for Federal employment
Travel may be required to conferences.
Bargaining Unit Position: No
Qualifications
BASIC REQUIREMENTS:
DEGREE: ENGINEERING. To be acceptable, the program must: (1) lead to a bachelor's degree in a school of engineering with at least one program accredited by ABET; or (2) include differential and integral calculus and courses (more advanced than first-year physics and chemistry) in five of the following seven areas of engineering science or physics: (a) statics, dynamics; (b) strength of materials (stress-strain relationships); (c) fluid mechanics, hydraulics; (d) thermodynamics; (e) electrical fields and circuits; (f) nature and properties of materials (relating particle and aggregate structure to properties); and (g) any other comparable area of fundamental engineering science or physics, such as optics, heat transfer, soil mechanics, or electronics.
OR
COMBINATION OF EDUCATION AND EXPERIENCE -- college-level education, training, and/or technical experience that furnished a thorough knowledge of the physical and mathematical sciences underlying engineering, and (2) a good understanding, both theoretical and practical, of the engineering sciences and techniques and their applications to one of the branches of engineering. The adequacy of such background must be demonstrated by one of the following:
1.Professional registration or licensure-- Current registration as an Engineer Intern (EI), Engineer in Training (EIT)1, or licensure as a Professional Engineer (PE) by any State, the District of Columbia, Guam, or Puerto Rico. Absent other means of qualifying under this standard, those applicants who achieved such registration by means other than written test (e.g., State grandfather or eminence provisions) are eligible only for positions that are within or closely related to the specialty field of their registration. For example, an applicant who attains registration through a State Board's eminence provision as a manufacturing engineer typically would be rated eligible only for manufacturing engineering positions.
2.Written Test-- Evidence of having successfully passed the Fundamentals of Engineering (FE)2 examination or any other written test required for professional registration by an engineering licensure board in the various States, the District of Columbia, Guam, and Puerto Rico.
Applicants who have passed the EIT examination and have completed all the requirements for either (a) a bachelor's degree in engineering technology (BET) from an accredited college of university that included 60 semester hours of courses in the physical, mathematical, and engineering sciences, or (b) a BET from a program accredited by the Accreditation Board for Engineering and Technology (ABET) may be rated eligible for certain engineering positions at GS-5. Eligibility is limited to positions that are within or closely related to the specialty field of the engineering technology program. Applicants for positions that involve highly technical research, development, or similar functions requiring an advanced level of competence in basic science must meet the basic requirements in paragraph A. Because of the diversity in kind and quality of BET programs, graduates of other BET programs are required to complete at least 1 year of additional education or highly technical work experience of such nature as to provide reasonable assurance of the possession of the knowledge, skills, and abilities required for professional engineering competence. The adequacy of this background must be demonstrated by passing the EIT examination.
3.Specified academic courses -- Successful completion of at least 60 semester hours of courses in the physical, mathematical, and engineering sciences and that included the courses specified in the basic requirements under paragraph A. The courses must be fully acceptable toward meeting the requirements of an engineering program as described in paragraph A
4.Related curriculum-- Successful completion of a curriculum leading to a bachelor's degree in an appropriate scientific field, e.g., engineering technology, physics, chemistry, architecture, computer science, mathematics, hydrology, or geology, may be accepted in lieu of a bachelor's degree in engineering, provided the applicant has had at least 1 year of professional engineering experience acquired under professional engineering supervision and guidance. Ordinarily there should be either an established plan of intensive training to develop professional engineering competence, or several years of prior professional engineering-type experience, e.g., in interdisciplinary positions. (The above examples of related curricula are not all-inclusive.)
Note: An applicant who meets the basic requirements as specified in A or B above, except as noted under B.1., may qualify for positions in any branch of engineering unless selective factors indicate otherwise.
IN ADDITION TO THE BASIC QUALIFICATION listed above: All applicants must have one year (52 weeks) of specialized experience equivalent to at least the GS-09 level (or ZP-II at NIST). Specialized experience is defined as experience:
1) Performing liquid chromatographic analysis of critical quality attributes of RNA-based biotherapeutics,
2) Performing mass spectrometric analysis of RNA-based biotherapeutics to detect and characterize impurities, AND
3) Interpreting research data and summarizing findings in presentations and publications.
OR
Master's or equivalent graduate degree
OR
A combination of education and experience
Experience refers to paid and unpaid experience, including volunteer work done through National Service programs (e.g., Peace Corps, AmeriCorps) and other organizations (e.g., professional; philanthropic; religious; spiritual; community, student, social). Volunteer work helps build critical competencies, knowledge, and skills and can provide valuable training and experience that translates directly to paid employment. You will receive credit for all qualifying experience, including volunteer experience.
The qualification requirements in this vacancy announcement are based on the U.S. Office of Personnel Management (OPM) Qualification Standards Handbook.
If requesting reconsideration of your qualification determination, please refer to the following site: Applicant Reconsideration
Education
This position has an education requirement. Transcripts must be submitted to validate that the education requirement has been met. Unofficial transcripts will be accepted in the application package. However, an official copy will be required before a final offer of employment.
Use of foreign education for qualifications. An accredited organization must evaluate education completed outside of the U.S. to ensure that it is comparable to education received in accredited institutions in the U.S. Click here to view a listing of accredited organizations from the Department of Education's website. A copy of the foreign education evaluation (containing the results with course-by-course listing) is required with your application.
Additional information
This position is covered under NIST's Alternative Personnel Management System (APMS), a pay-for-performance system with excellent HR flexibilities to help NIST recruit and retain top talent. Learn more about the APMS here!
We may share your application package with other selecting officials. Additional selections may be made through this vacancy.
Click all links in this vacancy announcement to view additional information or instructions.
You MUST select at least ONE ELIGIBILITY to be considered for this position.
All documents submitted for this announcement must be legible to make qualification or eligibility determinations.
A trial period may be required.
This appointment may be extended up to four years without further competition.
NIST strives to build a flexible and encouraging work environment to bring out the best in our employees. To help our employees balance responsibilities at home and at work, NIST offers a variety of work-life flexibilities. For more information, please visit our Careers website.
Candidates should be committed to improving the efficiency of the Federal government, passionate about the ideals of our American republic, and committed to upholding the rule of law and the United States Constitution.
A career with the U.S. government provides employees with a comprehensive benefits package. As a federal employee, you and your family will have access to a range of benefits that are designed to make your federal career very rewarding. Opens in a new windowLearn more about federal benefits.
Eligibility for benefits depends on the type of position you hold and whether your position is full-time, part-time or intermittent. Contact the hiring agency for more information on the specific benefits offered.
How you will be evaluated
You will be evaluated for this job based on how well you meet the qualifications above.
Please prepare a resume that is no longer than two pages; only the first two pages will be considered during the review process. Ensure your font is 11 points or larger and upload your resume as a .pdf document. This helps ensure your formatting looks exactly the way you intended.
How you will be evaluated: You will be evaluated for this job based on how well you meet the qualifications above. Once the announcement has closed, a review of your resume and supporting documentation will be used to determine whether you meet the qualification requirements listed in this announcement. Overstating your qualifications and/or experience in your application materials or application questionnaire may result in your removal from consideration.
Subject Matter Experts (SMEs) may be used to review your resume to determine your technical qualifications for this position based on the required specialized experience. SMEs will review ONLY two (2) pages of your resume. SMEs will not review additional information beyond your resume.
Applications will be assessed on the following competencies:
Chemistry
Manufacturing
Research
Technology Application
Referral: All applicants may be referred to the selecting official for consideration. Under Direct Hire Authority, applicants are not rated and ranked, and veteran preference does not apply.
CTAP or ICTAP eligibility: If you are a displaced or surplus Federal employee eligible for the Career Transition Assistance Plan (CTAP) or Interagency Career Transition Assistance Plan (ICTAP), you must be determined eligible and rated as well-qualified to receive special selection priority. "Well Qualified" means that in addition to meeting the minimum qualification requirements and selective placement factor(s), if applicable, you must receive a score of 85 or higher. Please review the following site regarding required documents to support CTAP or ICTAP eligibility and additional information regarding this authority - CTAP/ICTAP Eligibility
A career with the U.S. government provides employees with a comprehensive benefits package. As a federal employee, you and your family will have access to a range of benefits that are designed to make your federal career very rewarding. Opens in a new windowLearn more about federal benefits.
Eligibility for benefits depends on the type of position you hold and whether your position is full-time, part-time or intermittent. Contact the hiring agency for more information on the specific benefits offered.
A complete application includes: 1) A resume (not to exceed two pages), 2) vacancy question responses regarding technical qualifications, and 3) submission of any required documents. Please note that if you do not provide all required information, as specified in this announcement, or if the documents submitted are illegible you may not be considered for this position (or may not receive the special consideration for which you may be eligible).
Resume: All applicants must submit a resume by creating one in USAJOBS or uploading one of their choosing. Please prepare a resume no longer than 2 pages; only the first 2 pages will be considered during the review process. Ensure your font is 11 points or larger and upload your resume as a .pdf document. This helps ensure your formatting looks exactly the way you intended. Cover letters are optional. To receive any credit for relevant experience, please list the month/year and the number of hours worked for experience listed on your resume. We suggest you review the qualification requirements for this position as you may need to customize your resume to ensure that it supports the position qualifications. Please refer to the Resume Guidance on how to build an effective resume.
Please read the entire announcement and all the instructions before you begin an application. To apply and be considered for this position, you must complete all required questionnaires, assessments, and required documentation as specified in the How to Apply and Required Documents section. The complete application package must be submitted by 11:59 PM (ET) on the closing date of the announcement to receive consideration. The application process is as follows:
Click the Apply Online button.
Answer the questions presented in the application and attach all necessary supporting documentation.
Click the Submit Application button prior to 11:59 PM (ET) on the announcement closing date.
As part of the application process, you will be asked to respond to four narrative questions. While your responses to these questions is not required and will not be scored, we encourage you to thoughtfully address each question. You will be asked to certify that you are using your own words and did not use a consultant or artificial intelligence (AI) such as a large language model (LLM) like ChatGPT or Copilot.
Once your application has been submitted, you will receive a confirmation notification by email. The Human Resources Office will evaluate your application to determine your eligibility for the position. After the evaluation is complete, you will receive another notification regarding the status of your application.
To update your application, including supporting documentation: During the announcement open period, return to your USAJOBS account, find your application record, and click Edit my application. This option will no longer be available once the announcement has closed.
To view the announcement status or your application status: Click on this: USAJOBS Help Center - How to see your application and job status Your application status page is where you can view your application status, USA Hire assessment completion status, and review your notifications sent by the hiring agency regarding your application.
Need help applying?
If you are experiencing any difficulties with the online application process (anything after you have clicked the 'Apply Online' button), please contact the Agency Contact listed on this announcement between regular business hours (8:00 a.m. - 4:00 p.m. ET). If you receive any kind of error message, please be ready to provide a screenshot or, at a minimum, the error message text and number. We will provide you with a technical support number for further assistance if necessary.
If you are having trouble with USAJOBS (searching for jobs, account password/profile issues, or Resume Builder), please visit the USAJOBS USAJOBS Help Center - How to.... We regret that we are unable to support any issues with USAJOBS, as this service is not maintained by the NIST.
If you are experiencing a significant hardship that hinders your ability to apply online, please contact the Agency Contact listed on this announcement prior to the vacancy closing date and during regular business hours to discuss your situation.
Biomolecular Measurement Division
100 Bureau Drive
Gaithersburg, MD 20899
US
Next steps
We will update applicant statuses when:
A qualification determination is made. If found not qualified/eligible, no additional updates will be provided.
Applications are referred to the selecting official.
A selection decision has been made.
Please notify us if your contact information changes after announcement's closing date. Also, note that if you provide an inaccurate email address or if your mailbox is full or blocked (e.g., spam-blocker), you may not receive important communication, which could affect your consideration for this position.
The Federal hiring process is set up to be fair and transparent. Please read the following guidance.
A complete application includes: 1) A resume (not to exceed two pages), 2) vacancy question responses regarding technical qualifications, and 3) submission of any required documents. Please note that if you do not provide all required information, as specified in this announcement, or if the documents submitted are illegible you may not be considered for this position (or may not receive the special consideration for which you may be eligible).
Resume: All applicants must submit a resume by creating one in USAJOBS or uploading one of their choosing. Please prepare a resume no longer than 2 pages; only the first 2 pages will be considered during the review process. Ensure your font is 11 points or larger and upload your resume as a .pdf document. This helps ensure your formatting looks exactly the way you intended. Cover letters are optional. To receive any credit for relevant experience, please list the month/year and the number of hours worked for experience listed on your resume. We suggest you review the qualification requirements for this position as you may need to customize your resume to ensure that it supports the position qualifications. Please refer to the Resume Guidance on how to build an effective resume.
Please read the entire announcement and all the instructions before you begin an application. To apply and be considered for this position, you must complete all required questionnaires, assessments, and required documentation as specified in the How to Apply and Required Documents section. The complete application package must be submitted by 11:59 PM (ET) on the closing date of the announcement to receive consideration. The application process is as follows:
Click the Apply Online button.
Answer the questions presented in the application and attach all necessary supporting documentation.
Click the Submit Application button prior to 11:59 PM (ET) on the announcement closing date.
As part of the application process, you will be asked to respond to four narrative questions. While your responses to these questions is not required and will not be scored, we encourage you to thoughtfully address each question. You will be asked to certify that you are using your own words and did not use a consultant or artificial intelligence (AI) such as a large language model (LLM) like ChatGPT or Copilot.
Once your application has been submitted, you will receive a confirmation notification by email. The Human Resources Office will evaluate your application to determine your eligibility for the position. After the evaluation is complete, you will receive another notification regarding the status of your application.
To update your application, including supporting documentation: During the announcement open period, return to your USAJOBS account, find your application record, and click Edit my application. This option will no longer be available once the announcement has closed.
To view the announcement status or your application status: Click on this: USAJOBS Help Center - How to see your application and job status Your application status page is where you can view your application status, USA Hire assessment completion status, and review your notifications sent by the hiring agency regarding your application.
Need help applying?
If you are experiencing any difficulties with the online application process (anything after you have clicked the 'Apply Online' button), please contact the Agency Contact listed on this announcement between regular business hours (8:00 a.m. - 4:00 p.m. ET). If you receive any kind of error message, please be ready to provide a screenshot or, at a minimum, the error message text and number. We will provide you with a technical support number for further assistance if necessary.
If you are having trouble with USAJOBS (searching for jobs, account password/profile issues, or Resume Builder), please visit the USAJOBS USAJOBS Help Center - How to.... We regret that we are unable to support any issues with USAJOBS, as this service is not maintained by the NIST.
If you are experiencing a significant hardship that hinders your ability to apply online, please contact the Agency Contact listed on this announcement prior to the vacancy closing date and during regular business hours to discuss your situation.
Biomolecular Measurement Division
100 Bureau Drive
Gaithersburg, MD 20899
US
Next steps
We will update applicant statuses when:
A qualification determination is made. If found not qualified/eligible, no additional updates will be provided.
Applications are referred to the selecting official.
A selection decision has been made.
Please notify us if your contact information changes after announcement's closing date. Also, note that if you provide an inaccurate email address or if your mailbox is full or blocked (e.g., spam-blocker), you may not receive important communication, which could affect your consideration for this position.
Fair and transparent
The Federal hiring process is set up to be fair and transparent. Please read the following guidance.
