The Office of Research and Development (ORD) is seeking an internationally recognized science leader for the position of Endocrinologist in the National Center for Computational Toxicology (NCCT) in Durham (Research Triangle Park), North Carolina. Learn more about NCCT at http://www2.epa.gov/aboutepa/about-national-center-computational-toxicology-ncct .
ORD is filling this position using EPA's Title 42 Authority, which offers up to 5-year renewable term appointments at highly competitive, market-based salaries. The salary may be up to $250,000 per year, dependent upon qualifications, experience and other factors (e.g., current salary). The position is part of a larger EPA effort to use state-of-the-science approaches and technologies in its mission of protecting human health and the environment.
SPECIAL NOTE: The position is subject to the Ethics in Government Act of 1978. Appointment will be subject to applicant's completion of a background security investigation and favorable adjudication. Also, appointment will be subject to applicant's completion of a financial disclosure process which includes completing an OGE Form 278, Public Financial Disclosure Report.
The Office of Research and Development (ORD), National Center for Computational Toxicology (NCCT) provides scientific leadership, understanding and tools related to the application of mathematical and computer models to technologies derived from computational chemistry, molecular biology and systems biology in order to improve the Agency’s data reporting requirements, priority setting approaches to understanding chemical toxicity, and risk assessment approaches. The incumbent investigates the interactions of environmental and industrial chemicals with the endocrine system, including interactions with receptors, signal transduction pathways, hormone synthesis, release, and metabolism, and cross-talk between pathways. The incumbent is expected to primarily use in vitro approaches to identify relevant molecular interactions and perturbations and computational approaches for connecting the molecular interactions with tissue/organ-level responses of endocrine effects. The initial focus is expected to lie on the estrogen, androgen, and thyroid systems, but with time it is expected the incumbent will enlarge the scope of the program to include other aspects of the endocrine system. The incumbent works collaboratively with computational systems biologists to create models of endocrine action.
The incumbent’s research and leadership results in methods and approaches that evaluate and prioritize environmental and industrial chemicals based on the potential to disrupt the endocrine system in order to contribute to the Agency’s mission of increasing chemical safety and sustainability for the protection of human health and the environment. In particular, the incumbent leads the development of in vitro and in silico approaches leveraging the basic principles of endocrinology into tools that regulators, researchers, and practitioners uses to develop strategies for chemical risk assessment and management.
In addition to conducting and leading endocrine-related research, the incumbent:
- Works with EPA senior leadership to provide technical direction that integrates ORD’s endocrine disruptor research program across other Agency initiatives, and establishes a robust scientific capacity that supports multidisciplinary Agency applications.
- Helps the Agency identify critical research and technical issues involved with applying the research outputs in developing sustainable environmental solutions.
- Communicates complex scientific concepts to a broad range of stakeholders, partners, and interested parties.
- Serves as a senior advisor to NCCT and ORD on computational and in vitro systems for evaluating the hazards of environmental stressors that adversely impact endocrine systems.
- Provides guidance, training, and support in these subject areas to scientists throughout EPA in their application to risk assessment and agency policy-setting.
- Represents the NCCT, ORD and the Agency in relevant outside activities, particularly in the translation of these activities to the fields of toxicology, exposure science and risk assessment.