Job Overview

Summary

The Office of Research and Development (ORD) is seeking an internationally recognized science leader for the position of Computational/Medicinal Chemist in the National Center for Computational Toxicology (NCCT) in Durham (Research Triangle Park), North Carolina.  Learn more about NCCT at http://www2.epa.gov/aboutepa/about-national-center-computational-toxicology-ncct .

ORD is filling this position using EPA's Title 42 Authority, which offers up to 5-year renewable term appointments at highly competitive, market-based salaries. The salary may be up to $200,000 per year, dependent upon qualifications, experience and other factors (e.g., current salary). The position is part of a larger EPA effort to use state-of-the-science approaches and technologies in its mission of protecting human health and the environment.
SPECIAL NOTE:  The position is subject to the Ethics in Government Act of 1978. Appointment will be subject to applicant's completion of a background security investigation and favorable adjudication. Also, appointment will be subject to applicant's completion of a financial disclosure process which includes completing an OGE Form 278, Public Financial Disclosure Report.

Duties

The Office of Research and Development (ORD), National Center for Computational Toxicology (NCCT) provides scientific leadership, understanding and tools related to the application of mathematical and computer models to technologies derived from computational chemistry, molecular biology and systems biology in order to improve the Agency’s data reporting requirements, priority setting approaches to understanding chemical toxicity, and risk assessment approaches.  The incumbent conducts research and provides leadership for the development and application of computational chemistry or knowledge-driven medicinal chemistry approaches to identify chemical features associated with specific biological interactions or modes of action and predict specific manifestations of toxicity of environmental and industrial chemicals.  These interactions cover both reactive chemistry and weak interactions (e.g., receptor binding, enzyme inhibition).  The incumbent works collaboratively with biochemists and life scientists to construct and test hypotheses.

The incumbent’s research and leadership result in methods and approaches that have the potential to contribute to the Agency’s mission of increasing chemical safety and sustainability for the protection of human health and the environment.  In particular, the incumbent leverages the principles of computational or medicinal chemistry in the development of tools that chemical regulators, researchers, and practitioners use to predict the hazard, pharmacokinetic, and exposure-related properties of new and legacy chemicals or as an adjunct to mode of action in risk assessment.   
 
In addition to conducting and leading a research program, the incumbent:
- Works with EPA senior leadership to provide technical direction that integrates ORD’s chemical safety and sustainability research across Agency initiatives, and establishes a robust scientific capacity that supports multidisciplinary Agency applications.
- Uses his or her expertise to help the Agency identify critical research and technical issues involved with the design of greener products.  
- Communicates complex scientific concepts to a broad range of stakeholders, partners, and interested parties. 
- Serves as a senior advisor to NCCT and ORD on computational or medicinal chemistry issues related to exposure and effects of environmental and industrial chemicals.
- Provides guidance, training, and support in these subject areas to scientists throughout EPA in their application to risk assessment and agency policy-setting.  
- Represents the NCCT, ORD and the Agency in relevant outside activities, particularly in the translation of these activities to the fields of toxicology, exposure science and risk assessment.